Histamine provocation test

Measuring airway hypersensitivity. You will receive histamine (an irritant but harmless substance) through nebulisation. This substance may cause airway narrowing.

Appointments

Functiemetingen 6

Medical prescription required

You will always need a prescription from your doctor for this test. Bring this prescription with you on the day of the test.

Preparation

  • Do not smoke for 4 hours before the test.
  • Certain medications must not be taken prior to the test. Your doctor will inform you about this.

Procedure

Duration: 75 minutes

  • A staff member checks your baseline lung function (spirometry) before starting the test.
  • You then inhale various concentrations of histamine vapour.
  • After each nebulisation, the baseline lung function is measured.
  • The test ends when all concentrations have been administered, or if a specific reaction in the airways is triggered.
  • A bronchodilator will then be given to you using a spacer (plastic reservoir between the mouth and the inhaler).

Based on the airway response, it will be determined whether asthmatic symptoms (coughing and breathlessness) can be induced.

Histamine-provocatietest

Safe

The provocation test is a safe procedure. After the test, you may experience mild throat irritation or a tickling cough.

The test is demanding due to the frequent blowing required but is otherwise not dangerous.

Side effects

Airway reactions are possible and will be treated with medication.

Mild breathlessness during and after the test is normal. A bronchodilator will be given to resolve this.

Last edit: 28 january 2025