Klinische studies over pulmonale hypertensie

Lopende studies

• ADVANCE CAPACITY: A study evaluating the safety and effects of Ralinepag on exercise capacity assessed by cardiopulmonary exercise testing in subjects with PAH.
   
• ADVANCE EXTENSION: A Study Evaluating the Long-Term Efficacy and Safety of Ralinepag in Subjects With PAH Via an Open-Label Extension.
   
• ADVANCE OUTCOMES: A Study Evaluating the Efficacy and Safety of Ralinepag to Improve Treatment Outcomes in PAH Patients (Ralinepag/placebo).
   
• CADENCE: A Study to Evaluate the Effects of Sotatercept versus Placebo for the Treatment of Combined Postcapillary and Precapillary Pulmonary Hypertension due to Heart Failure with Preserved Ejection Fraction.
   
• COMPERA REGISTER: Prospective registry of newly initiated therapies for pulmonary hypertension.
   
• ELEVATE 2: A Study evaluating the effects of Rodatristat Ethyl in Patients with Pulmonary Arterial Hypertension.
   
• EXPOSURE Register.
   
• GB002-2102 (Open-label Extension Study of GB002 in Adult Subjects With Pulmonary Arterial Hypertension (PAH))
   
• HYPERION: Study to Evaluate Sotatercept When Added to Background Pulmonary Arterial Hypertension Therapy in Newly Diagnosed Intermediate- and High-risk PAH Patients.
   
• INSIGNIA: Study to Evaluate the Efficacy and Safety of MK-5475 in Adults with Pulmonary Arterial Hypertension.
   
• INS1009-202: Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Treprostinil Palmitil Inhalation Powder in Participants with Pulmonary Arterial Hypertension.
   
• INS1009-211: Study to Evaluate the Safety and Tolerability of Treprostinil Palmitil Inhalation Powder in Participants with Pulmonary Hypertension Associated with Interstitial Lung Disease.
   
• IMPAHCT: A Dose Ranging and Confirmatory Study to Evaluate the Safety and Efficacy of AV-101 in Patients with Pulmonary Arterial Hypertension.
   
• SALTO: A Study of Selexipag as Add-On Treatment to Standard of Care in Children With Pulmonary Arterial Hypertension.
   
• SOTERIA: An Open-Label Long-term Follow-up Study to Evaluate the Effects of Sotatercept When Added to Background Pulmonary Arterial Hypertension Therapy for the Treatment of PAH.
   
• UMBRELLA: A Clinical Study to Investigate the Long-term Safety of the Drug Macitentan in Patients With Pulmonary Hypertension Who Were Previously Treated With Macitentan in Clinical Studies.
   
• UNISUS: Outcome Study Assessing a 75 Milligrams (mg) Dose of Macitentan in Patients With Pulmonary Arterial Hypertension.
   
• ZENITH: A Study of Sotatercept for the Treatment of Pulmonary Arterial Hypertension in patients with high risk of mortality.

Toekomstige studies

• AV-101-003 (Inhaled iMatinib Pulmonary Arterial Hypertension Clinical Trial - Follow Up Long Term Extension (IMPAHCT-FUL) (IMPAHCT-FUL))
   
• INSIGNIA-COPD (MK-5475-013 INSIGNIA-PH-COPD: A Study of the Efficacy and Safety of MK-5475 (an Inhaled sGC Stimulator) in Adults With PH-COPD)
   
• INS1009-203 (A Study to Assess the Safety, Tolerability, and Effectiveness of the Long-Term Use of Treprostinil Palmitil Inhalation Powder (TPIP) in Participants With Pulmonary Arterial Hypertension (PAH))
   
• INS1009-211 (An Extension Study to Assess the Safety, Tolerability, and Effectiveness of the Long-Term Use of Treprostinil Palmitil Inhalation Powder (TPIP) in Participants With Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD))
   
• PLATYPUS (A Prospective, Open-label, Platform Study for Long-term Follow-up of Participants Using Study Intervention in Pulmonary Hypertension Parent Studies)